Overview
Welcome to the website for the 10th conference on Antiepileptic Drug Trials, held every two years and sponsored by the New York University Medical Center and The Epilepsy Study Consortium as well as the University of Pennsylvania Epilepsy Center and The Epilepsy Therapy Development Project .
If you have any questions about the conference, please contact Mary Ann Brodie in the NYU Comprehensive Epilepsy Center at:
Goals of the Conference
This is the tenth conference focusing on issues related to antiepileptic drug (AED) development from preclinical discoveries through clinical evaluations. In 2008 as many antiepileptic drugs are in the pipeline as at any time in the past. There is a always opportunity to learn from the past as we move into the future. This symposium will bring together representatives from academia, industry, the NIH, and the FDA to review what has been learned and to discuss strategies to enhance AED development.
Objectives
During the course of the meeting, participants will:
- Obtain an understanding of the processes by which new drugs are discovered, including discussion of new animal models and molecular targets.
- Discuss the potential for clinical trials of epilepsy prevention (antiepileptogenesis).
- Discuss the advantages and disadvantages of monotherapy trial designs and possible alternatives.
- Discuss options for novel phase II and III trial designs.
- Discuss with FDA representatives new objectives and legislation that have an impact on AED development.
- Explore methods for obtaining proof of principle for new AEDs, including time to Nth seizure.
- Discuss novel methods of drug delivery.
- Discuss the impact of generic AEDs on clinical trials in epilepsy, and on the epilepsy marketplace.
- Discuss trial designs for devices.
